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Anesth Analg 1985; 64:30-33
© 1985 International Anesthesia Research Society
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Dose-related Prolongation of the Bleeding Time by Intravenous Nitroglycerin

Peter R. Lichtenthal, MD, Ennio C. Rossi, MD, Gerlinde Louis, Karen A. Rehnberg, BS, Leonard D. Wade, MS, Lawrence L. Michaelis, MD, Ho-Leung Fung, PhD, and Paola Patrignani, ScD

Departments of Anesthesia, Medicine, and Surgery, Northwestern University School of Medicine, Chicago, Illinois; the Department of Pharmaceutics, SUNY, Buffalo, New York; and the Department of Pharmacology, Catholic University, Rome, Italy.

Abstract

The effects of intravenous nitroglycerin (NTG) upon the bleeding time, platelet aggregation response, and plasma 6-keto-PGF1{alpha} concentration were measured in 17 patients about to undergo coronary bypass grafting. NTG produced a dose-related prolongation of the bleeding time that correlated with the accompanying decrease in systolic blood pressure. Platelet aggregation was not affected and measurements of 6-keto-PGF1{alpha} Failed to reveal detectable levels (< 10 pg/ml) either before or after NTG infusion. This suggests that the prolonged bleeding time associated with NTG infusion may be due to vasodilation and increased venous capacitance, rather than altered vascular-platelet interaction.

Key Words: PHARMACOLOGY—nitroglycerin • ANESTHETIC TECHNIQUES • HYPOTENSIVE—nitroglycerine • BLOOD—coagulation




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1985 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1985 by the International Anesthesia Research Society.