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Anesth Analg 1993; 77:427-435
© 1993 International Anesthesia Research Society
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Effect of Vasopressin on Hemodynamic Variables, Organ Blood Flow, and Acid-Base Status in a Pig Model of Cardiopulmonary Resuscitation

Karl H. Lindner, MD, Alexander Brinkmann, MD, Ernst G. Pfenninger, MD, Keith G. Lurie, MD, Axel Goertz, MD, and Ingrid M. Lindner, MD

Department of Anesthesiology and Critical Care Medicine, University of Ulm, Ulm, Germany, and Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota

Based upon the hypothesis that vasopressin (antidiuretic hormone) may increase vascular resistance during ventricular fibrillation, the effects of this potent vasoconstrictor were studied in a porcine model of ventricular fibrillation. Vasopressin therapy was compared to epinephrine by randomly allocating 14 pigs to receive either 0.045 mg/kg of epinephrine (n = 7) or 0.8 U/kg of vasopressin (n = 7) after 4 min of ventricular fibrillation and 3 min of open-chest cardiopulmonary resuscitation. During cardiopulmonary resuscitation, myocardial blood flow before and 90 s and 5 min after drug administration was 57 ± 11, 84 ± 11, and 59 ± 9 mL-min–1100 g–1 (mean ± SEM) in the epinephrine group, and 61 ± 5, 148 ± 26, and 122 ± 22 mL-min–1-100 g–1 in the vasopressin group (P < 0.05 at 90 s and 5 min). At the same times, mean cardiac index was not significantly different between the groups. After drug administration, coronary venous Pco2 was significantly higher and coronary venous pH was significantly lower in the epinephrine as compared to the vasopressin group. All pigs in both groups were resuscitated and survived the 2-h observation period. We conclude that vasopressin improves vital organ perfusion during ventricular fibrillation and cardiopulmonary resuscitation. Vasopressin seems to be at least as effective as epinephrine in this pig model of ventricular fibrillation.




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Lippincott, Williams & Wilkins Anesthesia & Analgesia® is published for the International Anesthesia Research Society® by Lippincott Williams & Wilkins and Stanford University Libraries' HighWire Press®. Copyright 1993 by the International Anesthesia Research Society. Online ISSN: 1526-7598   Print ISSN: 0003-2999 HighWire Press
Copyright © 1993 by the International Anesthesia Research Society.